Art. 15 — Regulation (EC) No 1223/2009

CMR substances (Categories 1A, 1B and 2) in EU cosmetics

1,035CMR-classified substances

What are CMR substances?

CMR substances are those classified as Carcinogenic (Carc.), Mutagenic (Muta.) or Toxic for Reproduction (Repr.) under Regulation (EC) No 1272/2008 (CLP). The categories are: 1A (known effect, with evidence in humans), 1B (presumed effect, mainly based on animal data) and 2 (suspected effect, with limited evidence).

Article 15 of Regulation (EC) No 1223/2009 prohibits the use of CMR substances of categories 1A, 1B and 2 in cosmetic products. The exceptions differ depending on the category: a category 2 substance may be used only if the SCCS has assessed it and considered it safe for cosmetic use. For category 1A or 1B, all conditions of Article 15 must also be met: food safety (Regulation (EC) No 178/2002), absence of suitable documented alternatives, a specific use with known exposure, and a favourable SCCS opinion. How the complete mechanism works (CLP → Art. 15 → Annex II) →

This list is updated periodically through European Commission Regulations (the CMR 'Omnibus' Regulations), following updates to the CLP Regulation. BD-API synchronises these changes automatically and notifies connected systems, ensuring that formulations are always audited against the current version.

CMR substances in CosIng

INCI NameCMR ClassificationAnnexRef. No.
Carcinogenic Cat. 1A()Anx. II1461
Carcinogenic Cat. 1A()Anx. II1458
Carcinogenic Cat. 1A()Anx. II976
Carcinogenic Cat. 1A()Anx. II1462
Carcinogenic Cat. 1A()Anx. II334
Carcinogenic Cat. 1A()Anx. II1457
Carcinogenic Cat. 1A()Anx. II726
Carcinogenic Cat. 1A()Anx. II761
Carcinogenic Cat. 1A()Anx. II1463
Carcinogenic Cat. 1A()Anx. II1440
Carcinogenic Cat. 1A()Anx. II971
Carcinogenic Cat. 1A()Anx. II1448
Carcinogenic Cat. 1A()Anx. II974
Carcinogenic Cat. 1A()Anx. II1421
Carcinogenic Cat. 1A()Anx. II969
Carcinogenic Cat. 1A()Anx. II664
Carcinogenic Cat. 1A()Anx. II456
Carcinogenic Cat. 1A()Anx. II979
Carcinogenic Cat. 1A()Anx. II1464
Carcinogenic Cat. 1A()Anx. II1445
Carcinogenic Cat. 1A()Anx. II1442
Carcinogenic Cat. 1A()Anx. II1439
Carcinogenic Cat. 1A()Anx. II977
Carcinogenic Cat. 1A()Anx. II1451
Carcinogenic Cat. 1A()Anx. II1450
Carcinogenic Cat. 1A()Anx. II1446
Carcinogenic Cat. 1A()Anx. II970
Carcinogenic Cat. 1A()Anx. II972
Carcinogenic Cat. 1A()Anx. II762
Carcinogenic Cat. 1A()Anx. II714
Carcinogenic Cat. 1A()Anx. II717
Carcinogenic Cat. 1A()Anx. II716
Carcinogenic Cat. 1A()Anx. II713
Carcinogenic Cat. 1A()Anx. II968
Carcinogenic Cat. 1A()Anx. II973
Carcinogenic Cat. 1A()Anx. II1455
Carcinogenic Cat. 1A()Anx. II975
Carcinogenic Cat. 1A()Anx. II978
Carcinogenic Cat. 1A()Anx. II1454
Carcinogenic Cat. 1A()Anx. II614
Carcinogenic Cat. 1A()Anx. II457
Carcinogenic Cat. 1A()Anx. II1447
Carcinogenic Cat. 1A()Anx. II1444
Carcinogenic Cat. 1A()Anx. II1443
Carcinogenic Cat. 1A()Anx. II1449
Carcinogenic Cat. 1A()Anx. II1441
Carcinogenic Cat. 1A()Anx. II455
Carcinogenic Cat. 1A()Anx. II1438
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II1542
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II464
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II465
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II463
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II476
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II47
Carcinogenic Cat. 1A() Mutagenic Cat. 1B()Anx. II523
Carcinogenic Cat. 1A() Mutagenic Cat. 2()Anx. II460
Carcinogenic Cat. 1A() Mutagenic Cat. 2()Anx. II458
Carcinogenic Cat. 1A() Reprotoxic Cat. 1A()Anx. II1456
Carcinogenic Cat. 1A() Reprotoxic Cat. 1B() Mutagenic Cat. 2()Anx. II1060
Carcinogenic Cat. 1A() Reprotoxic Cat. 1B() Mutagenic Cat. 2()Anx. II1006
Carcinogenic Cat. 1A() Reprotoxic Cat. 1B() Mutagenic Cat. 2()Anx. II1100
Carcinogenic Cat. 1A() Reprotoxic Cat. 1B() Mutagenic Cat. 2()Anx. II1401
Carcinogenic Cat. 1A(C=>0.001%)Anx. II667
Carcinogenic Cat. 1A(C=>0.01%)Anx. II26
Carcinogenic Cat. 1A(C=>1%) Carcinogenic Cat. 1B() Mutagenic Cat. 2() Reprotoxic Cat. 2()Anx. II417
Carcinogenic Cat. 1B()Anx. II1540
Carcinogenic Cat. 1B()Anx. II638
Carcinogenic Cat. 1B()Anx. II639
Carcinogenic Cat. 1B()Anx. II640
Carcinogenic Cat. 1B()Anx. II1523
Carcinogenic Cat. 1B()Anx. II634
Carcinogenic Cat. 1B()Anx. II635
Carcinogenic Cat. 1B()Anx. II632
Carcinogenic Cat. 1B()Anx. II633
Carcinogenic Cat. 1B()Anx. II636
Carcinogenic Cat. 1B()Anx. II641
Carcinogenic Cat. 1B()Anx. II1474
Carcinogenic Cat. 1B()Anx. II1162
Carcinogenic Cat. 1B()Anx. II461
Carcinogenic Cat. 1B()Anx. II1123
Carcinogenic Cat. 1B()Anx. II1494
Carcinogenic Cat. 1B()Anx. II1207
Carcinogenic Cat. 1B()Anx. II631
Carcinogenic Cat. 1B()Anx. II642
Carcinogenic Cat. 1B()Anx. II1155
Carcinogenic Cat. 1B()Anx. II1158
Carcinogenic Cat. 1B()Anx. II1159
Carcinogenic Cat. 1B()Anx. II628
Carcinogenic Cat. 1B()Anx. II38
Carcinogenic Cat. 1B()Anx. II38
Carcinogenic Cat. 1B()Anx. II38
Carcinogenic Cat. 1B()Anx. II625
Carcinogenic Cat. 1B()Anx. II626
Carcinogenic Cat. 1B()Anx. II1205
Carcinogenic Cat. 1B()Anx. II627
Carcinogenic Cat. 1B()Anx. II629
Carcinogenic Cat. 1B()Anx. II1681
Carcinogenic Cat. 1B()Anx. II1632
Carcinogenic Cat. 1B()Anx. II201
Carcinogenic Cat. 1B()Anx. II1161

Showing 100 of 1035 ingredients

Automate Art. 15 compliance audits

BD-API detects when a substance in your formulation receives a CMR classification and notifies you in real time.

Request access →

Data source: official CosIng from the European Commission. BD-API does not replace professional regulatory advice.

Request access